PGD is the abbreviation for preimplant genetic diagnostics. This is a method that prevents the birth of children with a serious genetic disorder. PGD is performed in couples who have a high risk of a genetic disease, such as a chromosome aberration, haemophilia, Huntington's disease or severe muscular disease.
For PGD, an IVF treatment is necessary. In addition, after fertilization of ova cells outside the body, one cell is taken from embryos that are three days old. This cell is examined in the laboratory for the presence or absence of the disease in question. Only embryos without the genetic disease targeted by the study are placed in the uterus. The risk of post-placement pregnancy is about 25%.
PGD is used in couples at high risk of a child with severe genetic disease or high risk of loss of pregnancy due to a chromosomal aberration.
Couples who want to qualify for IVF / PGD should also meet the conditions for IVF. If the woman is forty years or older, the pair will no longer be eligible for PGD in the Netherlands. In case of overweight of the woman (BMI greater or equal to 30) no PGD is done.
The gynecologists or doctors of the IVF team will further investigate whether the pair is suitable for IVF. The latter is assessed among other things by means of hormone research in the woman and sperm research of the man.
Also see these information articles: · Hereditary disorders
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